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Dna Paternity Testing: Submitting Non-standard Samples (part 1)

DNA Paternity testing is the most accuratesamples can then be sent in sent in a normal
way of confirming biological relationshipsplastic or paper envelope and marked clearly
between individuals. The standard way ofas  a  non-standard  sample.
collecting samples from the individuals to be
tested is through the use of oral/buccalBone
swabs. Buccal swabs are relatively easy to
use and pain-free since the procedureBone samples are one of the most difficult
involves simply rubbing the swab on thematerials to obtain DNA from and not all DNA
inside of the mouth to collect a salivalaboratories offer the service. The success
sample. In addition, they can be easily sentrate will depend on the condition of the
by post to the client when they order a test.bones (e.g. how long the person has been
Hence, they provide an excellent medium todead, how his body has been preserved etc).
obtain  DNA  from  an  individual.When submitting bone samples it is normally
recommend that fragments from the shaft of
However, occasions arise when it is notthe femur or humerus are obtained weighing
possible to obtain the sample directly fromapproximately 2 grams per individual. It is
the individual, as for example in the case ofrecommended that the laboratory processing
a dead or missing person or samples collectedthe sample is contacted prior to taking the
from a crime scene. Therefore, in such cases,samples to discuss the case in advance.
it is possible to utilise alternative samplesCollection of samples should be performed by
(defined as non-standard samples), to obtaina  qualified  person.
the DNA of a person for the purpose of DNA
Testing.2. Everyday items that may contain DNA for
testing  purposes
The following list provides information about
a number of non-standard samples that can beCigarette  Butt
used  to  obtain  DNA  for  testing purposes.
Cigarette butts can be an excellent source of
1.  Direct  Biological  SamplesDNA if the sample has not been contaminated.
The more the cigarette has been smoked the
Hairmore DNA is likely to be available. If the
cigarette has been shared it is likely that a
Any hair submitted must have roots or themixed DNA profile will be obtained, in which
follicle attached. Hair that is cut will notcase more specialised analysis will be
produce significant DNA. When submitting arequired to separate the profiles. The client
hair sample, one must make sure not to touchshould make sure that the sample is not
the part with the follicle as much ashandled from the end used to inhale the
possible to avoid contamination. The hair cansmoke. Ideally the client will submit 2-4
be sent in a normal plastic or paper envelopecigarette butts if available. The butt can be
and marked clearly as a non-standard sample.sent in a normal plastic or paper envelope
The lab will normally require a minimum ofand  marked clearly as a non-standard sample.
6-10 hairs (or as many as possible) depending
on what is available. The more the hairsToothbrush
available, the more the chance of obtaining a
DNA  profile  from  them.A toothbrush can be a good source of DNA if
the sample has not been contaminated. The
Bloodmore the toothbrush has been used the more
DNA is likely to be available. If the
Blood samples can take various formstoothbrush has been shared it is possible
including whole blood, blood spots on paperthat a mixed DNA profile will be obtained in
or other material (tissues, clothing, andwhich case more specialised analysis will be
furniture), dried blood etc. Blood used to berequired. The client should make sure that
the most common form of submitting DNAthe sample is not handled from the end of the
samples for DNA paternity testing until thebristles to avoid contamination. Also the
advent of buccal swabs. It now rarelybrush should be air dried for about 30-60
requested as it is an invasive procedure asminutes to ensure that it is properly dried
opposed to the non-invasive and painlessbefore sending to the laboratory. The
nature of a buccal swab. Fresh blood sent intoothbrush can be sent in a normal plastic or
a normal tube will provide a more than enoughpaper envelope and marked clearly as a
sample for obtaining DNA. In cases wherenon-standard  sample.
blood is sent as spots on some form of
material, then the success of the extractionEnvelope  and  Stamp
will depend on the state of the blood and
whether it has been exposed to possibleLicked envelopes and stamps can provide a
contamination such as the elements, humansource of DNA for paternity testing purposes.
contamination  and/or  chemical  agents.However, the success rate on this type of
sample can very widely since it is not always
Nailspossible to know if the stamp and envelope
have been licked or not. In cases where there
It is also possible to extract DNA fromhas been no contact with a person's saliva
Nails. Freshly trimmed nails work best andthen it is clearly not possible to obtain
have the highest chance of success. Nails areDNA. Because of this, the sample is normally
normally recommended (apart from hair) inclassified as having a low rate of extraction
cases where the person has recently died. Itsuccess rate. When submitting the sample, it
is important to handle the nails with minimalis important to ensure not to touch the seals
direct contact as possible to avoidand the back of the stamp to minimise
contamination. The nails can be sent in apossible  contamination.
normal plastic or paper envelope and marked
clearly  as  a  non-standard  sample.Chewing  Gum
SpermChewing gum can be a good source of DNA if
the sample has not been contaminated by
In the case of liquid semen, it isexposure to contaminating agents. Sugar free
recommended that the sample is absorbedgum is preferred to normal type of gum. It is
through a clean cotton swab and air-dried forimportant to try not to touch the gum with
about one hour. In the case of dried sementhe fingers as this can lead to
stains, either send the material directly tocontamination. The gum can be sent in a
the laboratory or else absorb the stain ontonormal plastic or paper envelope and marked
a clean cotton swab moistened with distilledclearly as a non-standard sample.
water. Then air-dry for about an hour. The



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